MERFISH Report
1. Overview
1.1 Sample Information
A brief sample information is generated from the submission table for the following analysis.
| Batch | Index | Genotype | Time | Data Path | Region |
|---|---|---|---|---|---|
| 1 | tBHP_4_0 | tBHP | 4 | 202402021652_20240202MFisherBHP4hxm500VZG191x01_VMSC00101 | region_0 |
| 1 | tBHP_4_1 | tBHP | 4 | 202402021652_20240202MFisherBHP4hxm500VZG191x01_VMSC00101 | region_1 |
| 1 | PBS_4_0 | PBS | 4 | 202402021652_20240202MFisherBHP4hxm500VZG191x01_VMSC00101 | region_2 |
| 1 | PBS_4_1 | PBS | 4 | 202402021652_20240202MFisherBHP4hxm500VZG191x01_VMSC00101 | region_3 |
| 2 | PBS_24_0 | PBS | 24 | 202402021711_20240202MFisherBHP24hxm500VZG191x02_VMSC05201 | region_0 |
| 2 | PBS_24_1 | PBS | 24 | 202402021711_20240202MFisherBHP24hxm500VZG191x02_VMSC05201 | region_1 |
| 2 | tBHP_24_0 | tBHP | 24 | 202402021711_20240202MFisherBHP24hxm500VZG191x02_VMSC05201 | region_2 |
| 2 | tBHP_24_1 | tBHP | 24 | 202402021711_20240202MFisherBHP24hxm500VZG191x02_VMSC05201 | region_3 |
1.2 Data Quality
1.2.1 MERSCOPE Data Quality Summary
The summaries present the data quality assessment automatically generated by MERSCOPE for each experiment. We mainly focus on the transcripts level for each sample. So we’re looking for high density in transcripts, based on the transcripts count per field of view (FOV), transcript density in FOV, and frequency of transcripts detected.
Generally, log10 transcript count > 5.0 in most area can be considered as a good quality standard.
Need to note that the low accuracy in DAPI cell boundary is not a concern, as a self-designed cell segmentation processing will take over this task.
MERSCOPE Data Quality Summary
MERSCOPE Data Quality Summary
MERSCOPE Data Quality Summary
MERSCOPE Data Quality Summary
MERSCOPE Data Quality Summary
MERSCOPE Data Quality Summary
MERSCOPE Data Quality Summary
MERSCOPE Data Quality Summary
1.2.2 Transcript Count Level
Transcript counts on each sample
2. Data Processing
2.1 Cell Segmentation
Based on the spatial information and images obtained from MERFISH, we developed a machine learning model using the Cellpose algorithm to distinguish individual cells via MERFISH DAPI images.
To ensure the data quality and accuracy of cells, we have defined the minimum and maximum values for cell volume and gene count per cell. The cell volume should be between [100, 1800], and the gene count per cell > 25.
Outliers were filtered from the data, and the qualified cells count is presented in the following table. The identified cells after filtering are listed in the following table. In total, the study identified 122328 cells across 8 samples.
| Sample Index | Cell Count |
|---|---|
| tBHP_4_1 | 20452 |
| tBHP_4_0 | 18804 |
| tBHP_24_1 | 18206 |
| PBS_4_1 | 16603 |
| PBS_24_1 | 13900 |
| tBHP_24_0 | 13452 |
| PBS_24_0 | 12141 |
| PBS_4_0 | 8770 |
Identified Cell Spatial Overview on all Samples
–>
2.2 Cell Annotation
We use a recent published tool: Map My Cell to perform cell type annotations for each cell. It is a high resolution cell type annotator build by Alan Institude, with nested levels of classification including 34 classes and 338 subclasses.
The taxonomy is based on the Allen Mouse Brain Common Coordinate Framework version 3 (CCFv3)[https://doi.org/10.1016/j.cell.2020.04.007]. Part of the used abbreviations is list in the supplementary Abbreviation. Otherwise can be found in CCFv3 paper.
With the annotation, we can identify and plot the selected types of cells in each sample, and exclude uncertaine cells by bootstrapping probability < 0.9.
2.2.1 Cell Type Spatial Map
2.2.2 Endothelia & Microglia Spatial Map
2.2.3 Cell Type Count Table
| PBS_24 | PBS_4 | tBHP_24 | tBHP_4 | |
|---|---|---|---|---|
| Astrocyte | 2139 | 1856 | 2827 | 3004 |
| Endo | 603 | 678 | 1021 | 989 |
| L2/3 Glut | 547 | 317 | 903 | 1290 |
| L4/5 Glut | 1385 | 733 | 2010 | 2090 |
| L5 Glut | 563 | 501 | 901 | 1162 |
| L6 Glut | 299 | 205 | 404 | 718 |
| L6b Glut | 922 | 611 | 1223 | 1325 |
| Microglia | 445 | 518 | 581 | 1099 |
| OPC | 398 | 433 | 534 | 842 |
| Oligo | 2095 | 2308 | 3535 | 3061 |
| Peri | 319 | 296 | 513 | 601 |
| STR D1 GABA | 430 | 1763 | 609 | 2901 |
| STR D2 GABA | 824 | 2362 | 1043 | 3660 |
| TH Glut | 1117 | 459 | 726 | 46 |
3. Gene Differentiation
3.1 Data Mining for Ischemia & Hypoxia
We found the ischemia and hypoxia mouse gene list by searching public mouse genome database Mouse Genome Informatics (MGI). It provided related gene list by matching terms from validated resources, such as gene ontology pathways.
Overall, 94 genes are found by ischemia term, and 349 genes are found in hypoxia.
Among those, 30 genes are both in ischemia & hypoxia pathway, which are: Ccl2, Epo, Pgf, Aifm1, Aqp3, Bcl2, Casp9, Casr, Cav1, Cav3, Egr1, Hk2, Hyou1, Kcnj8, Kcnj11, Mir874, Ndnf, Nfe2l2, Nol3, Nppc, P2rx2, Pik3cb, Pink1, Ptk2b, Rest, Rock2, Stat3, Tigar, Trem2, Trp53.
3.1.1 Ischemia Gene List
| Type | MGI.ID | Symbol | Name | Chr | Start | End | Build | Strand | Best.Match.Type | Best.Match | Match.Score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| protein coding gene | MGI:98259 | Ccl2 | C-C motif chemokine ligand 2 | 11 | 81926403 | 81928278 | GRCm39 |
|
Disease Ortholog | ischemia | 4 |
| protein coding gene | MGI:108224 | Ccl12 | C-C motif chemokine ligand 12 | 11 | 81992671 | 81994225 | GRCm39 |
|
Disease Ortholog | ischemia | 4 |
| protein coding gene | MGI:106639 | Mthfr | methylenetetrahydrofolate reductase | 4 | 148123534 | 148144008 | GRCm39 |
|
Disease Ortholog | ischemia | 4 |
| lncRNA gene | MGI:5595308 | Cirpil | cardiac ischemia reperfusion associated p53 interacting lncRNA | 5 | 111638797 | 111640250 | GRCm39 |
|
Name | cardiac ischemia reperfusion associated p53 interacting lncRNA | 3 |
| QTL | MGI:3795764 | Lsq1 | loss of tissue after ischemia QTL 1 | 7 | syntenic | NA | GRCm39 | null | Name | loss of tissue after ischemia QTL 1 | 3 |
| protein coding gene | MGI:108448 | Angpt1 | angiopoietin 1 | 15 | 42288119 | 42540373 | GRCm39 |
|
Disease Ortholog | brain ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:96819 | Anxa1 | annexin A1 | 19 | 20350798 | 20368035 | GRCm39 |
|
Disease Ortholog | brain ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:108052 | Bcl2l2 | BCL2-like 2 | 14 | 55120900 | 55125691 | GRCm39 |
|
Disease Ortholog | transient cerebral ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:1339751 | Csf3 | colony stimulating factor 3 (granulocyte) | 11 | 98592089 | 98594455 | GRCm39 |
|
Disease Ortholog | brain ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:1859388 | Dll4 | delta like canonical Notch ligand 4 | 2 | 119156265 | 119166147 | GRCm39 |
|
Disease Ortholog | limb ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:95407 | Epo | erythropoietin | 5 | 137481282 | 137484078 | GRCm39 |
|
Disease Ortholog | limb ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:95412 | Ercc1 | excision repair cross-complementing rodent repair deficiency, complementation group 1 | 7 | 19079016 | 19090449 | GRCm39 |
|
Disease Ortholog | transient cerebral ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:99253 | Etv2 | ets variant 2 | 7 | 30333041 | 30335277 | GRCm39 |
|
Disease Ortholog | limb ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:1891012 | F12 | coagulation factor XII (Hageman factor) | 13 | 55565771 | 55574606 | GRCm39 |
|
Disease Ortholog | transient cerebral ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:95515 | Fgf1 | fibroblast growth factor 1 | 18 | 38971726 | 39062525 | GRCm39 |
|
Disease Ortholog | brain ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:95791 | Got1 | glutamic-oxaloacetic transaminase 1, soluble | 19 | 43488191 | 43513044 | GRCm39 |
|
Disease Ortholog | transient cerebral ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:96079 | Hgf | hepatocyte growth factor | 5 | 16758493 | 16825150 | GRCm39 |
|
Disease Ortholog | limb ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:96244 | Hspa1a | heat shock protein 1A | 17 | 35188335 | 35191132 | GRCm39 |
|
Disease Ortholog | brain ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:99517 | Hspa1b | heat shock protein 1B | 17 | 35175412 | 35178214 | GRCm39 |
|
Disease Ortholog | brain ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:96432 | Igf1 | insulin-like growth factor 1 | 10 | 87694127 | 87772904 | GRCm39 |
|
Disease Ortholog | brain ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:96547 | Il1rn | interleukin 1 receptor antagonist | 2 | 24226872 | 24241503 | GRCm39 |
|
Disease Ortholog | transient cerebral ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:96949 | Mdk | midkine | 2 | 91760149 | 91762348 | GRCm39 |
|
Disease Ortholog | brain ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:1929865 | Nampt | nicotinamide phosphoribosyltransferase | 12 | 32870334 | 32903368 | GRCm39 |
|
Disease Ortholog | transient cerebral ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:97362 | Nos3 | nitric oxide synthase 3, endothelial cell | 5 | 24569808 | 24589472 | GRCm39 |
|
Disease Ortholog | limb ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:105095 | Pgf | placental growth factor | 12 | 85213411 | 85224559 | GRCm39 |
|
Disease Ortholog | brain ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:1860488 | Proz | protein Z, vitamin K-dependent plasma glycoprotein | 8 | 13110914 | 13126026 | GRCm39 |
|
Disease Ortholog | brain ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:98278 | Sele | selectin, endothelial cell | 1 | 163875773 | 163885246 | GRCm39 |
|
Disease Ortholog | brain ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:108080 | Serpinf1 | serine (or cysteine) peptidase inhibitor, clade F, member 1 | 11 | 75300855 | 75313449 | GRCm39 |
|
Disease Ortholog | transient cerebral ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:98351 | Sod1 | superoxide dismutase 1, soluble | 16 | 90017650 | 90023221 | GRCm39 |
|
Disease Ortholog | transient cerebral ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:1095418 | Tfpi | tissue factor pathway inhibitor | 2 | 84263199 | 84307119 | GRCm39 |
|
Disease Ortholog | transient cerebral ischemia (subterm of ischemia) | 3 |
| protein coding gene | MGI:1926116 | Abraxas2 | BRISC complex subunit | 7 | 132460954 | 132486840 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1349419 | Aifm1 | apoptosis-inducing factor, mitochondrion-associated 1 | X | 47563821 | 47602440 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1333777 | Aqp3 | aquaporin 3 | 4 | 41092724 | 41098183 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:88138 | Bcl2 | B cell leukemia/lymphoma 2 | 1 | 106465908 | 106642004 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:88139 | Bcl2l1 | BCL2-like 1 | 2 | 152622588 | 152673648 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1346013 | Bves | blood vessel epicardial substance | 10 | 45211868 | 45248575 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:88256 | Camk2a | calcium/calmodulin-dependent protein kinase II alpha | 18 | 61058704 | 61121224 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1277950 | Casp9 | caspase 9 | 4 | 141520923 | 141543287 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1351351 | Casr | calcium-sensing receptor | 16 | 36314058 | 36382503 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:102709 | Cav1 | caveolin 1, caveolae protein | 6 | 17306387 | 17341323 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:107570 | Cav3 | caveolin 3 | 6 | 112436466 | 112449833 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1344418 | Cib1 | calcium and integrin binding 1 | 7 | 79876904 | 79882553 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1914829 | Cpeb4 | cytoplasmic polyadenylation element binding protein 4 | 11 | 31822211 | 31885634 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1339753 | Csf1 | colony stimulating factor 1 (macrophage) | 3 | 107648364 | 107667785 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1339758 | Csf1r | colony stimulating factor 1 receptor | 18 | 61238644 | 61264211 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1097153 | Cx3cl1 | C-X3-C motif chemokine ligand 1 | 8 | 95498808 | 95509055 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1333815 | Cx3cr1 | C-X3-C motif chemokine receptor 1 | 9 | 119877749 | 119897362 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1195261 | Eef2k | eukaryotic elongation factor-2 kinase | 7 | 120442080 | 120506441 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:95295 | Egr1 | early growth response 1 | 18 | 34994260 | 34998009 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1919643 | Faim2 | Fas apoptotic inhibitory molecule 2 | 15 | 99394893 | 99426046 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:95713 | Gja1 | gap junction protein, alpha 1 | 10 | 56253297 | 56266519 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:95720 | Gjb2 | gap junction protein, beta 2 | 14 | 57336059 | 57342159 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1354372 | Gpr31b | G protein-coupled receptor 31, D17Leh66b region | 17 | 13270208 | 13271167 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:96103 | Hk1 | hexokinase 1 | 10 | 62104634 | 62215687 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1315197 | Hk2 | hexokinase 2 | 6 | 82702006 | 82751435 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:108030 | Hyou1 | hypoxia up-regulated 1 | 9 | 44290840 | 44303662 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1100508 | Kcnj8 | potassium inwardly-rectifying channel, subfamily J, member 8 | 6 | 142510563 | 142517340 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:107501 | Kcnj11 | potassium inwardly rectifying channel, subfamily J, member 11 | 7 | 45746545 | 45750215 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1346867 | Map2k2 | mitogen-activated protein kinase kinase 2 | 10 | 80941749 | 80960531 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1346868 | Map2k3 | mitogen-activated protein kinase kinase 3 | 11 | 60822880 | 60843637 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1346870 | Map2k6 | mitogen-activated protein kinase kinase 6 | 11 | 110289948 | 110416348 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1346876 | Map3k5 | mitogen-activated protein kinase kinase kinase 5 | 10 | 19810218 | 20018499 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:99458 | Mef2c | myocyte enhancer factor 2C | 13 | 83652153 | 83815199 | GRCm39 |
|
Process | response to ischemia | 3 |
| miRNA gene | MGI:3718564 | Mir874 | microRNA 874 | 13 | 58170939 | 58171014 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1928485 | Mlycd | malonyl-CoA decarboxylase | 8 | 120121617 | 120137841 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1915419 | Ndnf | neuron-derived neurotrophic factor | 6 | 65648595 | 65689307 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:108420 | Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | 2 | 75505857 | 75534985 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1925938 | Nol3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 8 | 106002777 | 106008571 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:97369 | Nppc | natriuretic peptide type C | 1 | 86594015 | 86598295 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:97373 | Npr3 | natriuretic peptide receptor 3 | 15 | 11839982 | 11907287 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:103187 | Nqo1 | NAD(P)H dehydrogenase, quinone 1 | 8 | 108114857 | 108129838 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:2665170 | P2rx2 | purinergic receptor P2X, ligand-gated ion channel, 2 | 5 | 110487678 | 110491078 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1338859 | P2rx4 | purinergic receptor P2X, ligand-gated ion channel 4 | 5 | 122845607 | 122867801 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1860055 | Panx1 | pannexin 1 | 9 | 14917081 | 14956774 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1890615 | Panx2 | pannexin 2 | 15 | 88943937 | 88957770 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1195265 | Per2 | period circadian clock 2 | 1 | 91343704 | 91387046 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1922019 | Pik3cb | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta | 9 | 98920455 | 99022264 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1916193 | Pink1 | PTEN induced putative kinase 1 | 4 | 138040720 | 138053618 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:2145814 | Ppif | peptidylprolyl isomerase F (cyclophilin F) | 14 | 25694578 | 25700892 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:104908 | Ptk2b | PTK2 protein tyrosine kinase 2 beta | 14 | 66390706 | 66518501 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1890564 | Rcan1 | regulator of calcineurin 1 | 16 | 92188839 | 92263057 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:103290 | Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 19 | 5687511 | 5698158 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:104897 | Rest | RE1-silencing transcription factor | 5 | 77413338 | 77434279 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:107926 | Rock2 | Rho-associated coiled-coil containing protein kinase 2 | 12 | 16944896 | 17037824 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1915596 | Sirt5 | sirtuin 5 | 13 | 43518972 | 43548679 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:107996 | Slc8a2 | solute carrier family 8 (sodium/calcium exchanger), member 2 | 7 | 15863751 | 15894988 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1933154 | Slc26a5 | solute carrier family 26, member 5 | 5 | 22015653 | 22070602 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:98354 | Sos1 | SOS Ras/Rac guanine nucleotide exchange factor 1 | 17 | 80701181 | 80787882 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:107931 | Sqstm1 | sequestosome 1 | 11 | 50090193 | 50101654 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:103038 | Stat3 | signal transducer and activator of transcription 3 | 11 | 100777632 | 100830447 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:2442752 | Tigar | Trp53 induced glycolysis regulatory phosphatase | 6 | 127062079 | 127086520 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:1913150 | Trem2 | triggering receptor expressed on myeloid cells 2 | 17 | 48653429 | 48659304 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:98834 | Trp53 | transformation related protein 53 | 11 | 69471185 | 69482699 | GRCm39 |
|
Process | response to ischemia | 3 |
| protein coding gene | MGI:103149 | Uchl1 | ubiquitin carboxy-terminal hydrolase L1 | 5 | 66833464 | 66844577 | GRCm39 |
|
Process | response to ischemia | 3 |
3.1.2 Hypoxia Gene List
| Type | MGI.ID | Symbol | Name | Chr | Start | End | Build | Strand | Best.Match.Type | Best.Match | Match.Score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| protein coding gene | MGI:106918 | Hif1a | hypoxia inducible factor 1, alpha subunit | 12 | 73948149 | 73994304 | GRCm39 |
|
Name | hypoxia inducible factor 1, alpha subunit | 3 |
| protein coding gene | MGI:2442345 | Hif1an | hypoxia-inducible factor 1, alpha subunit inhibitor | 19 | 44551293 | 44564713 | GRCm39 |
|
Name | hypoxia-inducible factor 1, alpha subunit inhibitor | 3 |
| protein coding gene | MGI:1859778 | Hif3a | hypoxia inducible factor 3, alpha subunit | 7 | 16765432 | 16796352 | GRCm39 |
|
Name | hypoxia inducible factor 3, alpha subunit | 3 |
| protein coding gene | MGI:1916823 | Hilpda | hypoxia inducible lipid droplet associated | 6 | 29272487 | 29275445 | GRCm39 |
|
Name | hypoxia inducible lipid droplet associated | 3 |
| protein coding gene | MGI:108030 | Hyou1 | hypoxia up-regulated 1 | 9 | 44290840 | 44303662 | GRCm39 |
|
Name | hypoxia up-regulated 1 | 3 |
| protein coding gene | MGI:1932286 | Egln1 | egl-9 family hypoxia-inducible factor 1 | 8 | 125635326 | 125676063 | GRCm39 |
|
Name | egl-9 family hypoxia-inducible factor 1 | 3 |
| protein coding gene | MGI:1932287 | Egln2 | egl-9 family hypoxia-inducible factor 2 | 7 | 26858083 | 26866227 | GRCm39 |
|
Name | egl-9 family hypoxia-inducible factor 2 | 3 |
| protein coding gene | MGI:1932288 | Egln3 | egl-9 family hypoxia-inducible factor 3 | 12 | 54225767 | 54250646 | GRCm39 |
|
Name | egl-9 family hypoxia-inducible factor 3 | 3 |
| protein coding gene | MGI:3845761 | Methig1 | methyltransferase hypoxia inducible domain containing 1 | 15 | 100251081 | 100282316 | GRCm39 |
|
Name | methyltransferase hypoxia inducible domain containing 1 | 3 |
| protein coding gene | MGI:109169 | Epas1 | endothelial PAS domain protein 1 | 17 | 87061292 | 87140838 | GRCm39 |
|
Synonym | hypoxia inducible transcription factor 2alpha | 3 |
| protein coding gene | MGI:1930666 | Higd1a | HIG1 domain family, member 1A | 9 | 121677623 | 121686862 | GRCm39 |
|
Protein Domain | Hypoxia induced protein, domain | 3 |
| protein coding gene | MGI:1922939 | Higd1b | HIG1 domain family, member 1B | 11 | 102726675 | 102728866 | GRCm39 |
|
Protein Domain | Hypoxia induced protein, domain | 3 |
| protein coding gene | MGI:2685767 | Higd1c | HIG1 domain family, member 1C | 15 | 100262466 | 100281836 | GRCm39 |
|
Protein Domain | Hypoxia induced protein, domain | 3 |
| protein coding gene | MGI:1914294 | Higd2a | HIG1 domain family, member 2A | 13 | 54738044 | 54738960 | GRCm39 |
|
Protein Domain | Hypoxia induced protein, domain | 3 |
| protein coding gene | MGI:88574 | Cybb | cytochrome b-245, beta polypeptide | X | 9301493 | 9354005 | GRCm39 |
|
Process | hypoxia-inducible factor-1alpha signaling pathway | 3 |
| protein coding gene | MGI:1921693 | P4htm | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 9 | 108456061 | 108474866 | GRCm39 |
|
Function | hypoxia-inducible factor-proline dioxygenase activity | 3 |
| protein coding gene | MGI:1926119 | Pdk1 | pyruvate dehydrogenase kinase, isoenzyme 1 | 2 | 71703568 | 71734202 | GRCm39 |
|
Process | hypoxia-inducible factor-1alpha signaling pathway | 3 |
| protein coding gene | MGI:2384308 | Pdk3 | pyruvate dehydrogenase kinase, isoenzyme 3 | X | 92808213 | 92875807 | GRCm39 |
|
Process | hypoxia-inducible factor-1alpha signaling pathway | 3 |
| protein coding gene | MGI:103223 | Vhl | von Hippel-Lindau tumor suppressor | 6 | 113600955 | 113608595 | GRCm39 |
|
Process | hypoxia-inducible factor-1alpha signaling pathway | 3 |
| protein coding gene | MGI:109474 | Commd1 | COMM domain containing 1 | 11 | 22849728 | 22934539 | GRCm39 |
|
Subterm Process | negative regulation of hypoxia-inducible factor-1alpha signaling pathway (hypoxia-inducible factor-1alpha signaling pathway) | 3 |
| protein coding gene | MGI:1920420 | Rwdd3 | RWD domain containing 3 | 3 | 120949047 | 120965344 | GRCm39 |
|
Subterm Process | positive regulation of hypoxia-inducible factor-1alpha signaling pathway (hypoxia-inducible factor-1alpha signaling pathway) | 3 |
| protein coding gene | MGI:2443582 | Abat | 4-aminobutyrate aminotransferase | 16 | 8331293 | 8439432 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:97570 | Abcb1a | ATP-binding cassette, sub-family B member 1A | 5 | 8710077 | 8798575 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1352630 | Abcc9 | ATP-binding cassette, sub-family C member 9 | 6 | 142533588 | 142648041 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1098623 | Acaa2 | acetyl-CoA acyltransferase 2 | 18 | 74912283 | 74939278 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:87874 | Ace | angiotensin I converting enzyme | 11 | 105858774 | 105880790 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2159605 | Acot2 | acyl-CoA thioesterase 2 | 12 | 84034635 | 84040647 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1338946 | Acvrl1 | activin A receptor, type II-like 1 | 15 | 101026403 | 101043217 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:87916 | Ada | adenosine deaminase | 2 | 163568504 | 163592159 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:107825 | Adam8 | a disintegrin and metallopeptidase domain 8 | 7 | 139558845 | 139572475 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1333882 | Adam15 | ADAM metallopeptidase domain 15 | 3 | 89246947 | 89257589 | GRCm39 |
|
Process | response to hypobaric hypoxia | 3 |
| protein coding gene | MGI:1096335 | Adam17 | a disintegrin and metallopeptidase domain 17 | 12 | 21373510 | 21423633 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:106675 | Adipoq | adiponectin, C1Q and collagen domain containing | 16 | 22965286 | 22976718 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:108058 | Adm | adrenomedullin | 7 | 110226868 | 110229027 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2685083 | Ado | 2-aminoethanethiol dioxygenase | 10 | 67380341 | 67384785 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:99401 | Adora1 | adenosine A1 receptor | 1 | 134126963 | 134163169 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:87938 | Adrb2 | adrenergic receptor, beta 2 | 18 | 62310887 | 62313030 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:103202 | Adsl | adenylosuccinate lyase | 15 | 80832691 | 80855147 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:893592 | Ager | advanced glycosylation end product-specific receptor | 17 | 34816836 | 34819910 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:87965 | Agtr1b | angiotensin II receptor, type 1b | 3 | 20368637 | 20421341 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1339977 | Agtrap | angiotensin II, type I receptor-associated protein | 4 | 148161518 | 148172488 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1349419 | Aifm1 | apoptosis-inducing factor, mitochondrion-associated 1 | X | 47563821 | 47602440 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1341886 | Ajuba | ajuba LIM protein | 14 | 54804929 | 54815015 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:87979 | Ak4 | adenylate kinase 4 | 4 | 101276474 | 101324192 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:87986 | Akt1 | thymoma viral proto-oncogene 1 | 12 | 112620260 | 112641266 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:96853 | Alad | aminolevulinate, delta-, dehydratase | 4 | 62427406 | 62438155 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:87990 | Alas2 | aminolevulinic acid synthase 2, erythroid | X | 149330443 | 149353614 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1353451 | Aldh3a1 | aldehyde dehydrogenase family 3, subfamily A1 | 11 | 61099336 | 61109244 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2144489 | Alkbh5 | alkB homolog 5, RNA demethylase | 11 | 60428509 | 60449338 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88022 | Ang | angiogenin, ribonuclease, RNase A family, 5 | 14 | 51328607 | 51339462 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:104984 | Ang2 | angiogenin, ribonuclease A family, member 2 | 14 | 51432781 | 51436400 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1201793 | Ang3 | angiogenin, ribonuclease A family, member 3 | 14 | syntenic | NA | GRCm39 | null | Process | response to hypoxia | 3 |
| protein coding gene | MGI:2656551 | Ang4 | angiogenin, ribonuclease A family, member 4 | 14 | 52001349 | 52011047 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:3528599 | Ang5 | angiogenin, ribonuclease A family, member 5 | 14 | 44194526 | 44200537 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:3528602 | Ang6 | angiogenin, ribonuclease A family, member 6 | 14 | 44239121 | 44243875 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1202890 | Angpt2 | angiopoietin 2 | 8 | 18740279 | 18791578 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1336887 | Angpt4 | angiopoietin 4 | 2 | 151753130 | 151787257 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1888999 | Angptl4 | angiopoietin-like 4 | 17 | 33993874 | 34000549 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1306796 | Apaf1 | apoptotic peptidase activating factor 1 | 10 | 90825173 | 90918632 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:103201 | Aqp1 | aquaporin 1 | 6 | 55313417 | 55325540 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1333777 | Aqp3 | aquaporin 3 | 4 | 41092724 | 41098183 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:88071 | Arnt | aryl hydrocarbon receptor nuclear translocator | 3 | 95341699 | 95404551 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:107188 | Arnt2 | aryl hydrocarbon receptor nuclear translocator 2 | 7 | 83895486 | 84059201 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96920 | Ascl2 | achaete-scute family bHLH transcription factor 2 | 7 | 142520566 | 142523001 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:109349 | Atf2 | activating transcription factor 2 | 2 | 73646853 | 73722983 | GRCm39 |
|
Process | intrinsic apoptotic signaling pathway in response to hypoxia | 3 |
| protein coding gene | MGI:88096 | Atf4 | activating transcription factor 4 | 15 | 80139385 | 80141742 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:107202 | Atm | ataxia telangiectasia mutated | 9 | 53350449 | 53448040 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88108 | Atp1b1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 1 | 164264678 | 164285924 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1924148 | B3gat1 | beta-1,3-glucuronyltransferase 1 | 9 | 26644813 | 26672646 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1096330 | Bad | BCL2-associated agonist of cell death | 19 | 6919229 | 6929267 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:2181667 | Bbc3 | BCL2 binding component 3 | 7 | 16042318 | 16052130 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:88138 | Bcl2 | B cell leukemia/lymphoma 2 | 1 | 106465908 | 106642004 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1891828 | Becn1 | beclin 1, autophagy related | 11 | 101179084 | 101193112 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1197009 | Birc2 | baculoviral IAP repeat-containing 2 | 9 | 7818228 | 7837065 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88177 | Bmp2 | bone morphogenetic protein 2 | 2 | 133394079 | 133404805 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88184 | Bmyc | brain expressed myelocytomatosis oncogene | 2 | 25596891 | 25597733 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:109326 | Bnip3 | BCL2/adenovirus E1B interacting protein 3 | 7 | 138492565 | 138511235 | GRCm39 |
|
Process | intrinsic apoptotic signaling pathway in response to hypoxia | 3 |
| protein coding gene | MGI:1332659 | Bnip3l | BCL2/adenovirus E1B interacting protein 3-like | 14 | 67222688 | 67246326 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:2442836 | Brip1 | BRCA1 interacting protein C-terminal helicase 1 | 11 | 85948964 | 86092019 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1341265 | Camk2d | calcium/calmodulin-dependent protein kinase II, delta | 3 | 126389951 | 126639975 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88259 | Camk2g | calcium/calmodulin-dependent protein kinase II gamma | 14 | 20784943 | 20844156 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88264 | Capn2 | calpain 2 | 1 | 182294825 | 182345173 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2447188 | Car9 | carbonic anhydrase 9 | 4 | 43507026 | 43513729 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96544 | Casp1 | caspase 1 | 9 | 5298517 | 5307281 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:107739 | Casp3 | caspase 3 | 8 | 47070326 | 47092724 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1277950 | Casp9 | caspase 9 | 4 | 141520923 | 141543287 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1351351 | Casr | calcium-sensing receptor | 16 | 36314058 | 36382503 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:88271 | Cat | catalase | 2 | 103284249 | 103315498 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:102709 | Cav1 | caveolin 1, caveolae protein | 6 | 17306387 | 17341323 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:107570 | Cav3 | caveolin 3 | 6 | 112436466 | 112449833 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1338013 | Cbfa2t3 | CBFA2/RUNX1 translocation partner 3 | 8 | 123351880 | 123425848 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88279 | Cbl | Casitas B-lineage lymphoma | 9 | 44054273 | 44145346 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:88285 | Cbs | cystathionine beta-synthase | 17 | 31831602 | 31856170 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:98259 | Ccl2 | C-C motif chemokine ligand 2 | 11 | 81926403 | 81928278 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:108069 | Ccna2 | cyclin A2 | 3 | 36619014 | 36626299 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:106185 | Ccr2 | C-C motif chemokine receptor 2 | 9 | 123901987 | 123913594 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88323 | Cd24a | CD24a antigen | 10 | 43454433 | 43460261 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:107474 | Cd38 | CD38 antigen | 5 | 44026153 | 44069714 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:104565 | Cdkn1b | cyclin dependent kinase inhibitor 1B | 6 | 134897364 | 134902476 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1261428 | Chchd2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | 5 | 129910002 | 129916311 | GRCm39 |
|
Process | regulation of cellular response to hypoxia | 3 |
| pseudogene | MGI:3649942 | Chchd2-ps | coiled-coil-helix-coiled-coil-helix domain containing 2, pseudogene | 4 | 148152488 | 148152949 | GRCm39 |
|
Process | regulation of cellular response to hypoxia | 3 |
| protein coding gene | MGI:87888 | Chrna4 | cholinergic receptor, nicotinic, alpha polypeptide 4 | 2 | 180664104 | 180685339 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:87891 | Chrnb2 | cholinergic receptor nicotinic beta 2 subunit | 3 | 89660755 | 89671939 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1914813 | Ciao3 | cytosolic iron-sulfur assembly component 3 | 17 | 25992750 | 26002306 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1306784 | Cited2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 10 | 17598966 | 17601422 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1346342 | Clca1 | chloride channel accessory 1 | 3 | 144710298 | 144738537 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1329044 | Cldn3 | claudin 3 | 5 | 135015068 | 135016326 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88470 | Comt | catechol-O-methyltransferase | 16 | 18225636 | 18245602 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:108442 | Cpeb1 | cytoplasmic polyadenylation element binding protein 1 | 7 | 80996774 | 81105207 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:2442640 | Cpeb2 | cytoplasmic polyadenylation element binding protein 2 | 5 | 43390513 | 43447067 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1098296 | Cpt1a | carnitine palmitoyltransferase 1a, liver | 19 | 3372334 | 3435733 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88513 | Cr1l | complement C3b/C4b receptor 1 like | 1 | 194781019 | 194813878 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:88498 | Crhr1 | corticotropin releasing hormone receptor 1 | 11 | 104023681 | 104066349 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88515 | Cryaa | crystallin, alpha A | 17 | 31896905 | 31900704 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88516 | Cryab | crystallin, alpha B | 9 | 50662625 | 50667936 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2149481 | Cygb | cytoglobin | 11 | 116536421 | 116544887 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:88588 | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | 9 | 57595211 | 57611107 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1926218 | Cysltr1 | cysteinyl leukotriene receptor 1 | X | 105617952 | 105647285 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1917336 | Cysltr2 | cysteinyl leukotriene receptor 2 | 14 | 73263043 | 73286554 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1197015 | Daxx | Fas death domain-associated protein | 17 | 34128388 | 34134564 | GRCm39 |
|
Process | negative regulation of cellular response to hypoxia | 3 |
| protein coding gene | MGI:1916469 | Ddah1 | dimethylarginine dimethylaminohydrolase 1 | 3 | 145464447 | 145600032 | GRCm39 |
|
Process | negative regulation of cellular response to hypoxia | 3 |
| protein coding gene | MGI:1921997 | Ddit4 | DNA-damage-inducible transcript 4 | 10 | 59785497 | 59787592 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1345277 | Ddr2 | discoidin domain receptor family, member 2 | 1 | 169799876 | 169938331 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1306782 | Dio3 | deiodinase, iodothyronine type III | 12 | 110245664 | 110247531 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1921256 | Dnm1l | dynamin 1-like | 16 | 16130094 | 16176823 | GRCm39 |
|
Process | response to hypobaric hypoxia | 3 |
| protein coding gene | MGI:1261827 | Dnmt3a | DNA methyltransferase 3A | 12 | 3856007 | 3964443 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:94919 | Dpp4 | dipeptidylpeptidase 4 | 2 | 62160417 | 62242575 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:99578 | Drd1 | dopamine receptor D1 | 13 | 54205202 | 54209677 | GRCm39 |
|
Process | negative regulation of cellular response to hypoxia | 3 |
| protein coding gene | MGI:94924 | Drd2 | dopamine receptor D2 | 9 | 49251927 | 49319477 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1101357 | Ece1 | endothelin converting enzyme 1 | 4 | 137589548 | 137692540 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:95283 | Edn1 | endothelin 1 | 13 | 42454952 | 42461466 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:105923 | Ednra | endothelin receptor type A | 8 | 78389658 | 78451081 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:95295 | Egr1 | early growth response 1 | 18 | 34994260 | 34998009 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:103267 | Eif4ebp1 | eukaryotic translation initiation factor 4E binding protein 1 | 8 | 27750355 | 27765684 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:95392 | Eng | endoglin | 2 | 32536607 | 32572681 | GRCm39 |
|
Process | detection of hypoxia | 3 |
| protein coding gene | MGI:95393 | Eno1 | enolase 1, alpha non-neuron | 4 | 150321178 | 150333336 | GRCm39 |
|
Process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 3 |
| protein coding gene | MGI:3648653 | Eno1b | enolase 1B, retrotransposed | 18 | 48178402 | 48181446 | GRCm39 |
|
Process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 3 |
| protein coding gene | MGI:1276116 | Ep300 | E1A binding protein p300 | 15 | 81470329 | 81536278 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98277 | Epha4 | Eph receptor A4 | 1 | 77343822 | 77491725 | GRCm39 |
|
Process | negative regulation of cellular response to hypoxia | 3 |
| protein coding gene | MGI:95407 | Epo | erythropoietin | 5 | 137481282 | 137484078 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:95413 | Ercc2 | excision repair cross-complementing rodent repair deficiency, complementation group 2 | 7 | 19115942 | 19129619 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:95414 | Ercc3 | excision repair cross-complementing rodent repair deficiency, complementation group 3 | 18 | 32373357 | 32403206 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1354385 | Ero1a | endoplasmic reticulum oxidoreductase 1 alpha | 14 | 45520544 | 45556029 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:109325 | F7 | coagulation factor VII | 8 | 13076034 | 13085809 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:95479 | Fabp1 | fatty acid binding protein 1, liver | 6 | 71176863 | 71182018 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1917436 | Fam162a | family with sequence similarity 162, member A | 16 | 35864214 | 35891931 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:95558 | Flt1 | FMS-like tyrosine kinase 1 | 5 | 147498414 | 147662821 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1859252 | Fmn2 | formin 2 | 1 | 174329391 | 174650295 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1915905 | Fndc1 | fibronectin type III domain containing 1 | 17 | 7957401 | 8046134 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:95574 | Fos | FBJ osteosarcoma oncogene | 12 | 85520664 | 85524047 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:102858 | Fosl2 | fos-like antigen 2 | 5 | 32293145 | 32315186 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1890081 | Foxo3 | forkhead box O3 | 10 | 42057841 | 42152691 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1919268 | Fundc1 | FUN14 domain containing 1 | X | 17422803 | 17438564 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:108520 | Fzd4 | frizzled class receptor 4 | 7 | 89053574 | 89062341 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:95634 | Gad2 | glutamic acid decarboxylase 2 | 2 | 22512262 | 22583889 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:107516 | Gata6 | GATA binding protein 6 | 18 | 11052510 | 11085636 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:95781 | Gnb1 | guanine nucleotide binding protein (G protein), beta 1 | 4 | 155575818 | 155643726 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:109165 | Gngt1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 6 | 3993792 | 3997436 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:95821 | Grin2b | glutamate receptor, ionotropic, NMDA2B (epsilon 2) | 6 | 135690231 | 136150509 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1315197 | Hk2 | hexokinase 2 | 6 | 82702006 | 82751435 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96163 | Hmox1 | heme oxygenase 1 | 8 | 75820249 | 75827217 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:109373 | Hmox2 | heme oxygenase 2 | 16 | 4544225 | 4584606 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:109369 | Hp1bp3 | heterochromatin protein 1, binding protein 3 | 4 | 137943607 | 137971994 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:104720 | Hsd11b2 | hydroxysteroid 11-beta dehydrogenase 2 | 8 | 106245387 | 106250620 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98817 | Hsp90b1 | heat shock protein 90, beta (Grp94), member 1 | 10 | 86526705 | 86541308 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96542 | Il1a | interleukin 1 alpha | 2 | 129141530 | 129151892 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96552 | Il3 | interleukin 3 | 11 | 54156129 | 54158103 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:107936 | Il18 | interleukin 18 | 9 | 50466127 | 50493140 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96570 | Inhba | inhibin beta-A | 13 | 16186436 | 16206206 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1928268 | Ireb2 | iron responsive element binding protein 2 | 9 | 54771073 | 54819814 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:96600 | Itga2 | integrin alpha 2 | 13 | 114969617 | 115068636 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96623 | Itpr1 | inositol 1,4,5-trisphosphate receptor 1 | 6 | 108190057 | 108528070 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:99418 | Itpr2 | inositol 1,4,5-triphosphate receptor 2 | 6 | 146009797 | 146403721 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96662 | Kcna5 | potassium voltage-gated channel, shaker-related subfamily, member 5 | 6 | 126509514 | 126512375 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:102663 | Kcnd2 | potassium voltage-gated channel, Shal-related family, member 2 | 6 | 21215502 | 21729804 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1100508 | Kcnj8 | potassium inwardly-rectifying channel, subfamily J, member 8 | 6 | 142510563 | 142517340 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:107501 | Kcnj11 | potassium inwardly rectifying channel, subfamily J, member 11 | 7 | 45746545 | 45750215 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:109366 | Kcnk2 | potassium channel, subfamily K, member 2 | 1 | 188940127 | 189134470 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1100509 | Kcnk3 | potassium channel, subfamily K, member 3 | 5 | 30745514 | 30782614 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:99923 | Kcnma1 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 14 | 23342356 | 24055173 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1095419 | Kdm6a | lysine (K)-specific demethylase 6A | X | 18028814 | 18146175 | GRCm39 |
|
Process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 3 |
| protein coding gene | MGI:96683 | Kdr | kinase insert domain protein receptor | 5 | 76093487 | 76139118 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:104576 | Lct | lactase | 1 | 128212493 | 128256055 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:104663 | Lep | leptin | 6 | 29060220 | 29073875 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96787 | Lif | leukemia inhibitory factor | 11 | 4207587 | 4222514 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1352502 | Limd1 | LIM domains containing 1 | 9 | 123307771 | 123350617 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96794 | Lmna | lamin A | 3 | 88388455 | 88413842 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1921392 | Lonp1 | lon peptidase 1, mitochondrial | 17 | 56921297 | 56933887 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2137913 | Loxl2 | lysyl oxidase-like 2 | 14 | 69846517 | 69933283 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:104797 | Lta | lymphotoxin A | 17 | 35422141 | 35424327 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1346866 | Map2k1 | mitogen-activated protein kinase kinase 1 | 9 | 64093066 | 64160887 | GRCm39 |
|
Process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 3 |
| protein coding gene | MGI:96922 | Mb | myoglobin | 15 | 76899687 | 76934868 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96952 | Mdm2 | transformed mouse 3T3 cell double minute 2 | 10 | 117524780 | 117546663 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:99918 | Mecp2 | methyl CpG binding protein 2 | X | 73070198 | 73129296 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1914999 | Mgarp | mitochondria localized glutamic acid rich protein | 3 | 51295833 | 51303968 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:2146020 | Mief1 | mitochondrial elongation factor 1 | 15 | 80118284 | 80137572 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| miRNA gene | MGI:3618742 | Mir199a-2 | microRNA 199a-2 | 1 | 162045383 | 162045492 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| miRNA gene | MGI:2676890 | Mir214 | microRNA 214 | 1 | 162050937 | 162051046 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| miRNA gene | MGI:3629905 | Mir668 | microRNA 668 | 12 | 109701166 | 109701231 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| miRNA gene | MGI:3718564 | Mir874 | microRNA 874 | 13 | 58170939 | 58171014 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1929514 | Mlst8 | MTOR associated protein, LST8 homolog (S. cerevisiae) | 17 | 24692525 | 24698052 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:97009 | Mmp2 | matrix metallopeptidase 2 | 8 | 93553920 | 93580049 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:101900 | Mmp14 | matrix metallopeptidase 14 (membrane-inserted) | 14 | 54669055 | 54679913 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96080 | Mst1 | macrophage stimulating 1 (hepatocyte growth factor-like) | 9 | 107957635 | 107962202 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:95691 | Mstn | myostatin | 1 | 53100799 | 53107238 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:97173 | Mt3 | metallothionein 3 | 8 | 94879235 | 94880774 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:102504 | mt-Co1 | mitochondrially encoded cytochrome c oxidase I | MT | 5328 | 6872 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:102503 | mt-Co2 | mitochondrially encoded cytochrome c oxidase II | MT | 7013 | 7696 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:102501 | mt-Cytb | mitochondrially encoded cytochrome b | MT | 14145 | 15288 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:101787 | mt-Nd1 | mitochondrially encoded NADH dehydrogenase 1 | MT | 2751 | 3707 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:102498 | mt-Nd4 | mitochondrially encoded NADH dehydrogenase 4 | MT | 10167 | 11544 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:102496 | mt-Nd5 | mitochondrially encoded NADH dehydrogenase 5 | MT | 11742 | 13565 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1928394 | Mtor | mechanistic target of rapamycin kinase | 4 | 148533068 | 148642140 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:97250 | Myc | myelocytomatosis oncogene | 15 | 61857240 | 61862223 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:2137495 | Myocd | myocardin | 11 | 65067387 | 65160815 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1915419 | Ndnf | neuron-derived neurotrophic factor | 6 | 65648595 | 65689307 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:102570 | Ndp | Norrie disease (pseudoglioma) (human) | X | 16751760 | 16778013 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1341799 | Ndrg1 | N-myc downstream regulated gene 1 | 15 | 66801167 | 66841489 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:97306 | Nf1 | neurofibromin 1 | 11 | 79230519 | 79472438 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:103296 | Nfatc3 | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 | 8 | 106785472 | 106857169 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:108420 | Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | 2 | 75505857 | 75534985 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:2151886 | Ngb | neuroglobin | 12 | 87144305 | 87149313 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:97352 | Nkx3-1 | NK3 homeobox 1 | 14 | 69428141 | 69432107 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1925938 | Nol3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 8 | 106002777 | 106008571 | GRCm39 |
|
Process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 3 |
| protein coding gene | MGI:1855692 | Nono | non-POU-domain-containing, octamer binding protein | X | 100473080 | 100492199 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:2154441 | Nop53 | NOP53 ribosome biogenesis factor | 7 | 15671760 | 15680033 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:97361 | Nos2 | nitric oxide synthase 2, inducible | 11 | 78811613 | 78851052 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:97363 | Notch1 | notch 1 | 2 | 26347914 | 26393834 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1101358 | Npepps | aminopeptidase puromycin sensitive | 11 | 97096668 | 97171464 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:97369 | Nppc | natriuretic peptide type C | 1 | 86594015 | 86598295 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1352456 | Nr4a2 | nuclear receptor subfamily 4, group A, member 2 | 2 | 56996845 | 57014018 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1339639 | Ogt | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) | X | 100683666 | 100727957 | GRCm39 |
|
Process | negative regulation of cellular response to hypoxia | 3 |
| protein coding gene | MGI:97438 | Oprd1 | opioid receptor, delta 1 | 4 | 131838037 | 131871797 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:2665170 | P2rx2 | purinergic receptor P2X, ligand-gated ion channel, 2 | 5 | 110487678 | 110491078 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1097160 | P2rx3 | purinergic receptor P2X, ligand-gated ion channel, 3 | 2 | 84828927 | 84867806 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:97464 | P4hb | prolyl 4-hydroxylase, beta polypeptide | 11 | 120451124 | 120464079 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1339975 | Pak1 | p21 (RAC1) activated kinase 1 | 7 | 97437748 | 97561588 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:97501 | Pck1 | phosphoenolpyruvate carboxykinase 1, cytosolic | 2 | 172994866 | 173001067 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1860611 | Pdlim1 | PDZ and LIM domain 1 (elfin) | 19 | 40210683 | 40260060 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:104629 | Penk | preproenkephalin | 4 | 4133536 | 4138815 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:105095 | Pgf | placental growth factor | 12 | 85213411 | 85224559 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:97555 | Pgk1 | phosphoglycerate kinase 1 | X | 105230706 | 105247305 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:102520 | Phb2 | prohibitin 2 | 6 | 124689299 | 124693913 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1922019 | Pik3cb | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta | 9 | 98920455 | 99022264 | GRCm39 |
|
Process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 3 |
| protein coding gene | MGI:1346036 | Pin1 | peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 | 9 | 20563335 | 20575008 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:3649546 | Pin1rt1 | peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1, retrogene 1 | 2 | 104544271 | 104546724 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1916193 | Pink1 | PTEN induced putative kinase 1 | 4 | 138040720 | 138053618 | GRCm39 |
|
Process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 3 |
| protein coding gene | MGI:97610 | Plat | plasminogen activator, tissue | 8 | 23247743 | 23272860 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:97611 | Plau | plasminogen activator, urokinase | 14 | 20886728 | 20893453 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:892877 | Pld2 | phospholipase D2 | 11 | 70430890 | 70448936 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2387630 | Plekhn1 | pleckstrin homology domain containing, family N member 1 | 4 | 156305913 | 156312999 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:109604 | Plk3 | polo like kinase 3 | 4 | 116985852 | 116991160 | GRCm39 |
|
Process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia | 3 |
| protein coding gene | MGI:99907 | Plod1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 4 | 147994210 | 148021224 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:104662 | Pml | promyelocytic leukemia | 9 | 58125359 | 58157069 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1926321 | Postn | periostin, osteoblast specific factor | 3 | 54268530 | 54298458 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:104740 | Ppara | peroxisome proliferator activated receptor alpha | 15 | 85619184 | 85687020 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:101884 | Ppard | peroxisome proliferator activator receptor delta | 17 | 28451715 | 28520446 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:97747 | Pparg | peroxisome proliferator activated receptor gamma | 6 | 115337912 | 115467360 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:97749 | Ppia | peptidylprolyl isomerase A | 11 | 6365867 | 6369817 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2145955 | Prkaa1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | 15 | 5173343 | 5211380 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:97596 | Prkcb | protein kinase C, beta | 7 | 121888327 | 122233625 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:97599 | Prkce | protein kinase C, epsilon | 17 | 86475213 | 86965347 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1206587 | Prl4a1 | prolactin family 4, subfamily a, member 1 | 13 | 28200195 | 28207531 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:894281 | Prl8a2 | prolactin family 8, subfamily a, member 2 | 13 | 27529656 | 27538199 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1316652 | Prmt2 | protein arginine N-methyltransferase 2 | 10 | 76043060 | 76073699 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:109583 | Pten | phosphatase and tensin homolog | 19 | 32734977 | 32803560 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1097156 | Ptgis | prostaglandin I2 (prostacyclin) synthase | 2 | 167033725 | 167082524 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:97798 | Ptgs2 | prostaglandin-endoperoxide synthase 2 | 1 | 149975851 | 149983978 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:104908 | Ptk2b | PTK2 protein tyrosine kinase 2 beta | 14 | 66390706 | 66518501 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:97830 | Pygm | muscle glycogen phosphorylase | 19 | 6434438 | 6448494 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:108016 | Rad21 | RAD21 cohesin complex component | 15 | 51825636 | 51855143 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:97847 | Raf1 | v-raf-leukemia viral oncogene 1 | 6 | 115595530 | 115653596 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:97895 | Reg1 | regenerating islet-derived 1 | 6 | 78402966 | 78405651 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:104897 | Rest | RE1-silencing transcription factor | 5 | 77413338 | 77434279 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1913464 | Rgcc | regulator of cell cycle | 14 | 79526190 | 79539075 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:107926 | Rock2 | Rho-associated coiled-coil containing protein kinase 2 | 12 | 16944896 | 17037824 | GRCm39 |
|
Process | regulation of cellular response to hypoxia | 3 |
| protein coding gene | MGI:104661 | Rora | RAR-related orphan receptor alpha | 9 | 68561068 | 69295528 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1921620 | Rptor | regulatory associated protein of MTOR, complex 1 | 11 | 119493731 | 119790402 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1915835 | Rtn4 | reticulon 4 | 11 | 29642947 | 29694331 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:99659 | Ryr1 | ryanodine receptor 1, skeletal muscle | 7 | 28702765 | 28824599 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:99685 | Ryr2 | ryanodine receptor 2, cardiac | 13 | 11567988 | 12121831 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2135958 | Scap | SREBF chaperone | 9 | 110162356 | 110214017 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1924233 | Scfd1 | Sec1 family domain containing 1 | 12 | 51424296 | 51496887 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98248 | Scn2a | sodium channel, voltage-gated, type II, alpha | 2 | 65451115 | 65597791 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1914175 | Sdhd | succinate dehydrogenase complex, subunit D, integral membrane protein | 9 | 50507657 | 50515112 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:892014 | Sfrp1 | secreted frizzled-related protein 1 | 8 | 23901518 | 23939648 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:2135607 | Sirt1 | sirtuin 1 | 10 | 63154784 | 63174814 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1927664 | Sirt2 | sirtuin 2 | 7 | 28466192 | 28488086 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1922637 | Sirt4 | sirtuin 4 | 5 | 115616069 | 115622784 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:95755 | Slc2a1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 4 | 118965942 | 118994527 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:95758 | Slc2a4 | solute carrier family 2 (facilitated glucose transporter), member 4 | 11 | 69833365 | 69839014 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1860103 | Slc2a8 | solute carrier family 2, (facilitated glucose transporter), member 8 | 2 | 32863002 | 32872095 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:96285 | Slc6a4 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | 11 | 76889429 | 76923166 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:107956 | Slc8a1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | 17 | 81680534 | 82045806 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:107976 | Slc8a3 | solute carrier family 8 (sodium/calcium exchanger), member 3 | 12 | 81244689 | 81379954 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:102462 | Slc9a1 | solute carrier family 9 (sodium/hydrogen exchanger), member 1 | 4 | 133097022 | 133151013 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1345279 | Slc11a2 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 15 | 100285779 | 100322090 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1927073 | Slc29a1 | solute carrier family 29 (nucleoside transporters), member 1 | 17 | 45896126 | 45910532 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1201674 | Smad3 | SMAD family member 3 | 9 | 63554049 | 63665276 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:894293 | Smad4 | SMAD family member 4 | 18 | 73772080 | 73836851 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98352 | Sod2 | superoxide dismutase 2, mitochondrial | 17 | 13226726 | 13237006 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:103181 | Sod3 | superoxide dismutase 3, extracellular | 5 | 52521146 | 52527080 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98366 | Sox4 | SRY (sex determining region Y)-box 4 | 13 | 29132902 | 29137682 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98397 | Src | Rous sarcoma oncogene | 2 | 157265828 | 157313758 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:106658 | Srf | serum response factor | 17 | 46859255 | 46867101 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:103038 | Stat3 | signal transducer and activator of transcription 3 | 11 | 100777632 | 100830447 | GRCm39 |
|
Process | regulation of cellular response to hypoxia | 3 |
| protein coding gene | MGI:109131 | Stc1 | stanniocalcin 1 | 14 | 69266738 | 69278850 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1316731 | Stc2 | stanniocalcin 2 | 11 | 31309441 | 31320061 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1099440 | Suv39h1 | suppressor of variegation 3-9 1 | X | 7927410 | 7940999 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1890396 | Suv39h2 | suppressor of variegation 3-9 2 | 2 | 3456852 | 3476068 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1341163 | Tacc3 | transforming, acidic coiled-coil containing protein 3 | 5 | 33815472 | 33836339 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1351652 | Tbl2 | transducin (beta)-like 2 | 5 | 135178288 | 135192727 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:98664 | Tek | TEK receptor tyrosine kinase | 4 | 94627526 | 94763213 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1202709 | Tert | telomerase reverse transcriptase | 13 | 73775030 | 73797962 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:107810 | Tfam | transcription factor A, mitochondrial | 10 | 71061294 | 71074110 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98822 | Tfrc | transferrin receptor | 16 | 32427738 | 32451612 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98725 | Tgfb1 | transforming growth factor, beta 1 | 7 | 25386427 | 25404502 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:98726 | Tgfb2 | transforming growth factor, beta 2 | 1 | 186354989 | 186438186 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98727 | Tgfb3 | transforming growth factor, beta 3 | 12 | 86103519 | 86125815 | GRCm39 |
|
Process | detection of hypoxia | 3 |
| protein coding gene | MGI:98735 | Th | tyrosine hydroxylase | 7 | 142446516 | 142453732 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2442752 | Tigar | Trp53 induced glycolysis regulatory phosphatase | 6 | 127062079 | 127086520 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:2139220 | Tm9sf4 | transmembrane 9 superfamily member 4 | 2 | 153003223 | 153052386 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:99682 | Tmbim6 | transmembrane BAX inhibitor motif containing 6 | 15 | 99290828 | 99307930 | GRCm39 |
|
Process | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 3 |
| protein coding gene | MGI:104798 | Tnf | tumor necrosis factor | 17 | 35418357 | 35420983 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1913150 | Trem2 | triggering receptor expressed on myeloid cells 2 | 17 | 48653429 | 48659304 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:98823 | Trh | thyrotropin releasing hormone | 6 | 92219042 | 92221631 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98834 | Trp53 | transformation related protein 53 | 11 | 69471185 | 69482699 | GRCm39 |
|
Process | intrinsic apoptotic signaling pathway in response to hypoxia | 3 |
| protein coding gene | MGI:1926945 | Trpv4 | transient receptor potential cation channel, subfamily V, member 4 | 5 | 114760213 | 114796482 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:102548 | Tsc2 | TSC complex subunit 2 | 17 | 24814790 | 24851604 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98872 | Twist1 | twist basic helix-loop-helix transcription factor 1 | 12 | 34007670 | 34009828 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1929468 | Txn2 | thioredoxin 2 | 15 | 77799251 | 77813194 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1860276 | Ubqln1 | ubiquilin 1 | 13 | 58323970 | 58363467 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1932970 | Ucn3 | urocortin 3 | 13 | 3990688 | 3995349 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:109354 | Ucp2 | uncoupling protein 2 (mitochondrial, proton carrier) | 7 | 100142565 | 100148832 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1099787 | Ucp3 | uncoupling protein 3 (mitochondrial, proton carrier) | 7 | 100122198 | 100135639 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:99542 | Usf1 | upstream transcription factor 1 | 1 | 171238875 | 171246327 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:1918722 | Usp19 | ubiquitin specific peptidase 19 | 9 | 108367806 | 108379536 | GRCm39 |
|
Process | regulation of cellular response to hypoxia | 3 |
| protein coding gene | MGI:1346329 | Uts2 | urotensin 2 | 4 | 151081554 | 151086267 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2177651 | Vasn | vasorin | 16 | 4457805 | 4468666 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:103178 | Vegfa | vascular endothelial growth factor A | 17 | 46327919 | 46343295 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:106199 | Vegfb | vascular endothelial growth factor B | 19 | 6959841 | 6965019 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:109124 | Vegfc | vascular endothelial growth factor C | 8 | 54530567 | 54639489 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:108037 | Vegfd | vascular endothelial growth factor D | X | 163156374 | 163185646 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:98935 | Vldlr | very low density lipoprotein receptor | 19 | 27193884 | 27231631 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
| protein coding gene | MGI:1915086 | Wdr83 | WD repeat domain containing 83 | 8 | 85801664 | 85807375 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:2141920 | Wtip | WT1 interacting protein | 7 | 33808968 | 33832693 | GRCm39 |
|
Process | response to hypoxia | 3 |
| protein coding gene | MGI:99137 | Xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | 7 | 24246124 | 24272863 | GRCm39 |
|
Process | response to hypoxia | 3 |
| lncRNA gene | MGI:1916199 | Zfas1 | zinc finger, NFX1-type containing 1, antisense RNA 1 | 2 | 166904854 | 166907782 | GRCm39 |
|
Process | regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 3 |
| protein coding gene | MGI:107946 | Zfp36l1 | zinc finger protein 36, C3H type-like 1 | 12 | 80154534 | 80159787 | GRCm39 |
|
Process | cellular response to hypoxia | 3 |
3.2 Gene Differentiation Volcano
Here, we use Wilcoxon Test to compute gene differential expression (DE). The statistical significance was cut-off by log2(Fold Change) > 1 or log2(Fold Change) < -1 and p_value < 0.05.
The ischemia-related gene are highlighted in volcano plot by purple color, while hypoxia-related genes are marked in green. No ischemia-hypoxia-overlap gene is found in DE.
3.2.1 Microglia (4 hours), tBHP vs PBS
| logfoldchanges | pvals | |
|---|---|---|
| Selplg | 7.804862 | 0.0000000 |
| Apoe | -3.794668 | 0.0000000 |
| C1qa | 3.027765 | 0.0000000 |
| Slc17a7 | 1.934162 | 0.0001875 |
| Serpinf1 | -1.611794 | 0.0127633 |
| Nnat | -1.523112 | 0.0002573 |
| Ctss | 1.202592 | 0.0003786 |
| Cd9 | -1.000260 | 0.0068657 |
3.2.2 Microglia(24 hours), tBHP vs PBS
| logfoldchanges | pvals | |
|---|---|---|
| Tmem119 | 9.655052 | 0.0000000 |
| Cx3cr1 | 9.207951 | 0.0000000 |
| Csf1r | 7.521422 | 0.0000000 |
| C1qa | 6.288658 | 0.0000000 |
| Ctss | 4.346459 | 0.0000035 |
| Camk2a | 3.978816 | 0.0000000 |
| Bin1 | 2.346426 | 0.0000000 |
| Apoe | 1.898717 | 0.0000196 |
| Ctsb | 1.771201 | 0.0000000 |
| Plp1 | 1.656879 | 0.0022404 |
| Cd14 | 1.628826 | 0.0000000 |
| Cspg5 | 1.620137 | 0.0000051 |
| Aldh1l1 | 1.425023 | 0.0046848 |
| Trem2 | 1.414192 | 0.0002061 |
| Sncg | 1.364001 | 0.0245285 |
| Itgam | 1.336048 | 0.0000000 |
| Casp8 | 1.334647 | 0.0017914 |
| Rbfox3 | 1.271873 | 0.0096435 |
| Inpp5d | 1.213771 | 0.0000029 |
| Cd9 | 1.205624 | 0.0023450 |
| Spi1 | 1.185843 | 0.0004712 |
| Tcerg1 | 1.140319 | 0.0018037 |
| Sla | 1.096807 | 0.0000018 |
| Zbtb20 | 1.081156 | 0.0009113 |
| Nptx1 | 1.074096 | 0.0166972 |
| Lrpprc | 1.068678 | 0.0109181 |
| Sharpin | 1.065369 | 0.0195681 |
| Abi3 | 1.056846 | 0.0000005 |
| Syn1 | 1.051837 | 0.0025161 |
| Ctsc | 1.000470 | 0.0000616 |
3.2.3 Endothelial (4 hours), tBHP vs PBS
| logfoldchanges | pvals | |
|---|---|---|
| Icam1 | 4.321182 | 0.0000005 |
| Vcam1 | 1.990366 | 0.0359665 |
| Slc17a7 | 1.944467 | 0.0000000 |
| Agt | -1.849056 | 0.0004980 |
| Nnat | -1.548581 | 0.0000001 |
| Pecam1 | 1.424326 | 0.0000000 |
| Nptxr | 1.219218 | 0.0154648 |
| Klf2 | -1.188156 | 0.0000000 |
| Cldn5 | 1.106118 | 0.0166088 |
| Camk2a | 1.005879 | 0.0001490 |
3.2.4 Endothelial (24 hours), tBHP vs PBS
| logfoldchanges | pvals | |
|---|---|---|
| Bsg | 14.207772 | 0.0000000 |
| Cldn5 | 8.383662 | 0.0000000 |
| Apoe | 3.879512 | 0.0000000 |
| Camk2a | 3.245064 | 0.0000000 |
| App | 2.708132 | 0.0000033 |
| Flt1 | 2.425270 | 0.0000000 |
| Pecam1 | 2.256013 | 0.0000000 |
| Mfsd2a | 2.185250 | 0.0000000 |
| Ctnnb1 | 1.970689 | 0.0000000 |
| Gfap | 1.806280 | 0.0000364 |
| Kcnq1 | 1.715021 | 0.0091454 |
| Plp1 | 1.607371 | 0.0013174 |
| Cspg5 | 1.545747 | 0.0000000 |
| Cx3cl1 | 1.531581 | 0.0000054 |
| Nos3 | 1.520198 | 0.0000000 |
| Xdh | 1.502282 | 0.0000000 |
| Nptxr | 1.472057 | 0.0000195 |
| Ppp1r1b | 1.443743 | 0.0173912 |
| Klf2 | 1.395932 | 0.0000000 |
| Fn1 | 1.385187 | 0.0003460 |
| Sema3g | 1.272809 | 0.0486582 |
| Arc | -1.256589 | 0.0003183 |
| Stard8 | 1.242842 | 0.0001185 |
| Zbtb20 | 1.223462 | 0.0000000 |
| Rgs5 | 1.216236 | 0.0000001 |
| Lef1 | 1.192588 | 0.0000001 |
| Tcerg1 | 1.179086 | 0.0141037 |
| Ngrn | 1.148234 | 0.0371505 |
| Cdh5 | 1.141593 | 0.0000000 |
| Pcdhgc3 | 1.121873 | 0.0000000 |
| Grb2 | 1.105423 | 0.0009515 |
| Rbfox3 | 1.103138 | 0.0068434 |
| Syn1 | 1.100524 | 0.0012414 |
| Bin1 | 1.090345 | 0.0012565 |
| Syp | 1.079221 | 0.0020913 |
| Fam131a | 1.045174 | 0.0279760 |
| Lmna | 1.044754 | 0.0000058 |
| Dnm1 | 1.039805 | 0.0158126 |
Supplement: Abbreviation
Cell types & Regions
Astro, Astrocyte;
ABC, arachnoid barrier cells;
BAM, border-associated macrophages;
BLA, Basolateral amygdala;
CB, cerebellum;
CGE, caudal ganglionic eminence;
CHOR, choroid plexus;
CNU, cerebral nuclei;
CR, Cajal–Retzius;
CT, corticothalamic;
CTX, cerebral cortex;
CTXsp, cortical subplate;
DC, dendritic cells;
DCO, dorsal cochlear nucleus;
DG, dentate gyrus;
EA, extended amygdala;
Endo, endothelial cells;
ENT, Entorhinal area;
ENTl, Entorhinal area, lateral part;
Epen, ependymal;
EPI, epithalamus;
ET, extratelencephalic;
GC, granule cell;
HB, hindbrain;
HPF, hippocampal formation;
HY, hypothalamus;
HYa, anterior hypothalamic;
IMN, immature neurons;
IT, intratelencephalic;
L6b, layer 6b;
LGE, lateral ganglionic eminence;
LH, lateral habenula;
LSX, lateral septal complex;
MB, midbrain;
MGE, medial ganglionic eminence;
MH, medial habenula;
MM, medial mammillary nucleus;
MY, medulla;
NN, non-neuronal;
NP, near-projecting;
NT, non-telencephalon;
OB, olfactory bulb;
OEC, olfactory ensheathing cells;
OLF, olfactory areas;
Oligo, oligodendrocytes;
OPC, oligodendrocyte precursor cells;
P, pons;
PAL, pallidum;
Peri, pericytes;
PIR, piriform cortex;
SMC, smooth muscle cells;
STR, striatum;
TE, telencephalon;
TH, thalamus;
UBC, unipolar brush cells;
VLMC, vascular leptomeningeal cells.
Neurotransmitter types
Chol, cholinergic;
Dopa, dopaminergic;
GABA, GABAergic;
Glut, glutamatergic;
Glyc, glycinergic;
Hist, histaminergic;
Nora, noradrenergic;
Sero, serotonergic
ADP, anterodorsal preoptic nucleus
AHN, anterior hypothalamic nucleus
ARH, arcuate hypothalamic nucleus
CLI, central linear nucleus raphe
CUN, cuneiform nucleus
DMH, dorsomedial nucleus of the hypothalamus
DMX, dorsal motor nucleus of the vagus nerve
IF, interfascicular nucleus raphe
LHA, lateral hypothalamic area
MDRN, medullary reticular nucleus
MPN, medial preoptic nucleus
MPO, medial preoptic area
MV, medial vestibular nucleus
NTS, nucleus of the solitary tract
PAG, periaqueductal grey
PARN, parvicellular reticular nucleus
PB, parabrachial nucleus
PBG, parabigeminal nucleus
PGRN, paragigantocellular reticular nucleus
PGRNd, paragigantocellular reticular nucleus, dorsal part
PH, posterior hypothalamic nucleus
PMv, ventral premammillary nucleus
PPN, pedunculopontine nucleus
PVa, periventricular hypothalamic nucleus, anterior part
PVHd, paraventricular hypothalamic nucleus, descending division
PVi, periventricular hypothalamic nucleus, intermediate part
PVpo, periventricular hypothalamic nucleus, preoptic part
PVR, periventricular region
RAmb, midbrain raphe nuclei
RL, rostral linear nucleus raphe
SBPV, subparaventricular zone
SNc, substantia nigra, compact part
SPIV, spinal vestibular nucleus
TMv, tuberomammillary nucleus, ventral part
VII, facial motor nucleus
VMPO, ventromedial preoptic nucleus
VTA, ventral tegmental area
ZI, zona incerta.